Researchers at Augusta University in the US have found that a high-dose, two-week course of CBD can help restore brain function in Alzheimer’s sufferers.
According to Knowridge Science Report, the team discovered the treatment regime helped restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer’s disease, and improves cognition.
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Hi Conrad, I can’t find that information on the Journal of Alzheimer’s Disease website (https://www.j-alz.com/). The research was conducted on mice – see the abstract below.
Cheers, Martin
Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer’s Disease
Abstract: There is a dire need for due innovative therapeutic modalities to improve outcomes of AD patients. In this study, we tested whether cannabidiol (CBD) improves outcomes in a translational model of familial AD and to investigate if CBD regulates interleukin (IL)-33 and triggering receptor expressed on myeloid cells 2 (TREM2), which are associated with improved cognitive function. CBD was administered to 5xFAD mice, which recapitulate early onset, familial AD. Behavioral tests and immunoassays were used to evaluate cognitive and motor outcomes. Our findings suggest that CBD treatment enhanced IL-33 and TREM2 expression, ameliorated the symptoms of AD, and retarded cognitive decline.
Any idea what dosages were being used in the study?