A US study has shown CBD may be an effective treatment for postmenopausal women whose ovaries no longer make estrogen.
Rutgers University scientists found estrogen-deficient mice fed CBD burned more energy and their bloodstreams more readily disposed of glucose. Their bone density improved, inflammation in gut and bone tissues reduced and they had higher levels of beneficial gut bacteria.
Meanwhile, untreated estrogen-deficient mice developed symptoms that resembled those of postmenopausal women, such as metabolic dysfunction, evidence of inflammation, lower bone density, and lower levels of beneficial gut bacteria.
Senior author assistant professor Diana Roopchand said: “This preclinical study is the first to suggest the therapeutic potential of CBD for alleviating symptoms of estrogen deficiency.
“There is much anecdotal evidence of CBD’s health benefits for menopausal and postmenopausal women, but our study is the first to investigate some of the claims in an established preclinical model of postmenopause.”
Women in the postmenopausal stage, defined as one year after final menstruation and typically occurring around 50 years of age, experience a steep decline in estrogen levels that can lead to weight gain, cardiometabolic disease, osteoporosis, gastrointestinal disorders and cognitive decline.
Hormone replacement therapy (HRT) is one of the few treatment options, but clinical studies have indicated it can lead to greater risk of heart disease, stroke, blood clots and cancer in women over 60.
Roopchand added: “Other therapeutic options with fewer safety concerns are needed for prevention of chronic disease in this underserved demographic.
“CBD is already being used by many women to deal with symptoms of menopause and postmenopause. This study provides preclinical evidence to support further investigation of CBD as a therapeutic for postmenopause-related disorders.”
The study is published in Frontiers in Pharmacology.