Pharmacologists at the University of Sydney have found clues which could help solve the riddle of the entourage effect — why low-dose CBD products containing a full-spectrum of cannabinoids seem to have therapeutic impacts at relatively low doses.
The study, published in Scientific Reports, found that cannabinoids in a cannabis extract interact to produce much higher concentrations of cannabidiolic acid (CBDA) in the bloodstream than when CBDA is administered alone as a single molecule.
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